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Herbs from around the world to help with stress, fatigue, and the chaos of life
“What doesn’t bend breaks,” as the saying goes, and the degree to which we are expected to “bend” is ever increasing. Our ability to stay focused, adaptable, and calm is of the essence in our fast-paced, outcome-oriented culture. Although energy drinks and other stimulants offer quick fixes, their effects are not only short-lived, but also potentially harmful to health. Fortunately, an entire class of herbs may offer us stress-coping support and a sustainable energy boost. In addition to eating a balanced diet, exercising regularly, and getting enough sleep, these plants – aptly named adaptogens for their ability to help the body adapt to stress – can help us “bend” more deeply and gracefully.
Ashwagandha (Withania somnifera)
Ashwagandha has been shown to support both the brain and the body’s ability to deal with stress. In a double blind, randomized, placebo-controlled trial of adults experiencing chronic stress, supplementation with ashwagandha significantly reduced perceived stress levels, decreased food cravings, and improved happiness, while also reducing objective markers like cortisol levels and weight.[1] Stress also is a major contributor to gastric ulcers,[2] which ashwagandha has been shown to help prevent.[3]
Stress and disturbed sleep often go hand-in-hand, and thankfully ashwagandha may help with both. The herb has evidence it may not only buffer the negative effects of sleep deprivation on cognitive function,[4] but also may mitigate the associated inflammation, anxiety, and cellular injury and death.[5] Yet, as energizing as the plant can be, the Latin name somnifera reflects ashwagandha’s ability to enhance sleep quality,[6] largely due to its effects on the neurotransmitter gamma-aminobutyric acid (GABA).[7]
In men, ashwagandha has been shown in a variety of studies to improve sexual function and markers of fertility, increasing testosterone levels, sperm count and motility, and reducing oxidative stress, a contributor to infertility.
Stress can also impact sexual function, and ashwagandha seems to help with that too: the herb was shown in one study to support sexual function in females ages 21 to 50, improving not only arousal, but also sexual satisfaction.[8] In men, ashwagandha has been shown in a variety of studies to improve sexual function and markers of fertility, increasing testosterone levels, sperm count and motility, and reducing oxidative stress, a contributor to infertility.[9]
Holy Basil (Ocimum sanctum)
Holy basil has been used in the thousands of years-old system of Indian healing known as Ayurveda, and serves as a perfect example of how an ancient remedy can help us with modern ailments. Also known as tulsi, holy basil has been shown to help the body and mind cope with stress, largely through balancing the feedback systems of the brain and adrenal glands (which produce the stress hormone cortisol).[10] However, there is ever-growing evidence that holy basil can help with physical, chemical, metabolic, and psychological stresses through a variety of pharmacological actions.
Holy basil has data showing it may protect the body – the liver, kidney, and brain, specifically – against chemical stress from heavy metals, overdoses of pharmaceutical medications, and sources of industrial pollution, largely through its antioxidant effects.[11],[12],[13],[14] In animal studies, holy basil has also demonstrated efficacy in protecting the body against the harmful effects of oxygen deprivation, over-exertion, cold exposure, and exposure to loud noises.[15],[16],[17] These studies also show enhanced aerobic metabolism, improved swimming time (a measure of physical performance and depression in animals[18]), and a reduction of stress hormone levels, oxidative tissue damage,[19],[20],[21] and inflammation.[22]
In humans, holy basil has been shown to increase brain function, significantly improving reaction time, error rate, and other markers of function compared to placebo.[23] Animal models have shown it mitigates psychological stress and protects against age-related memory deficits, acting similarly to an acetylcholinesterase inhibitor.[24],[25]
In animals and humans, this herb has also been shown to help normalize blood sugar balance,[26],[27] cholesterol levels, [28] and reduce blood pressure,[29] thereby countering metabolic stress.
A six-week, randomized, double-blind, placebo-controlled study showed that holy basil not only significantly improved general stress scores, but also helped with sexual problems, sleep trouble, forgetfulness, and energy.
Holy basil also has been shown to ease the symptoms of both depression and anxiety,[30],[31],[32] with effects comparable to pharmaceutical antidepressants.[33] In fact, a six-week, randomized, double-blind, placebo-controlled study showed that holy basil not only significantly improved general stress scores, but also helped with sexual problems, sleep trouble, forgetfulness, and energy.[34] It is likely for these reasons that holy basil is also known as “liquid yoga.”[35]
Rhodiola (Rhodiola rosea)
Also known as golden root, rhodiola is commonly used in Russia and the Scandinavian countries where it grows. Like other adaptogens, rhodiola has been shown to fight fatigue, but is especially helpful in helping with the fatigue specifically associated with stress[36] as well as with chronic fatigue.[37]
In male students experiencing the stress of examinations, rhodiola was shown to increase learning capacity, reduce mental fatigue, and decrease situational anxiety.[38] Similar results were also reported in a study of military cadets, with improvements in mental capacity, coordination, physical work capacity, and general wellbeing.[39] In cases of physical stress, rhodiola has been shown in animal studies to reduce the risk of drug-induced arrhythmias (irregular heartbeat)[40] and to prevent stress-induced damage to the heart muscle.[41] It has further been shown in humans to enhance performance during endurance exercise such as running.[42]
In male students experiencing the stress of examinations, rhodiola was shown to increase learning capacity, reduce mental fatigue, and decrease situational anxiety.
In a study of over 100 people with life- and work-related stress, daily rhodiola supplementation yielded significant improvements in energy and mood after a mere three days, with improvements continuing throughout the four-week study.[43] In another study focusing on burnout in 118 participants, rhodiola was shown to lower stress levels and alleviate symptoms of depression.[44]
Several studies have suggested rhodiola’s likely impact on depression comes from its effects on neurotransmitters.[45],[46],[47] In one clinical trial, rhodiola was shown to help not only with depression, but also with insomnia and emotional stability.[48] Other studies suggest it also may help with self-esteem.[49],[50] Because rhodiola may impact the activity of neurotransmitters, in particular serotonin,[51] use in combination with medications for depression should only be done under the guidance of a knowledgeable medical practitioner.
Herbs from the family of adaptogens, known for their ability to help us cope with stress and life’s challenges, are found worldwide. This speaks not only to the commonality of stress, but also perhaps to nature’s interest in helping deal with it, no matter where in the world we may find ourselves.
Click here to see References
[1] Choudhary D, et al. Body weight management in adults under chronic stress through treatment with Ashwagandha root extract: a double-blind, randomized, placebo-controlled trial. J Evid Based Complementary Altern Med. 2017 Jan;22(1):96-106. [2] Filaretova LP. [Gastric stress ulcers: the protective role of hormones of the hypothalamo-hypophyseal-adrenocortical system]. Fiziol Zh Im I M Sechenova. 1995 Mar;81(3):50-60. [3] Singh N, et al. Withania somnifera (Ashwagandha), a rejuvenating herbal drug which enhances survival during stress (an adaptogen). Int J Crude Drug Res. 1982 Jan 1;20(1):29-35. [4] Manchanda S, et al. Aqueous leaf extract of Withania somnifera as a potential neuroprotective agent in sleep-deprived rats: a mechanistic study. Mol Neurobiol. 2017 May;54(4):3050-61. [5] Kaur T, et al. Withania somnifera as a potential anxiolytic and immunomodulatory agent in acute sleep deprived female Wistar rats. Mol Cell Biochem. 2017 Mar;427(1-2):91-101. [6] Kaushik MK, et al. Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction. PLoS One. 2017 Feb 16;12(2):e0172508. [7] Candelario M, et al. Direct evidence for GABAergic activity of Withania somnifera on mammalian ionotropic GABAA and GABAρ receptors. J Ethnopharmacol. 2015 Aug 2;171:264-72. [8] Dongre S, et al. Efficacy and safety of Ashwagandha (Withania somnifera) root extract in improving sexual function in women: a pilot study. Biomed Res Int. 2015;2015:284154. [9] Sengupta P, et al. Role of Withania somnifera (Ashwagandha) in the management of male infertility. Reprod Biomed Online. 2018 Mar;36(3):311-326. [10] Richard J, et al. Anti-stress activity of Ocimum sanctum: possible effects on hypothalamic-pituitary-adrenal axis. Phytother Res. 2016 May;30(5):805-14. [11] Shah K, Verma RJ. Protection against butyl p-hydroxybenzoic acid induced oxidative stress by Ocimum sanctum extract in mice liver. Acta Pol Pharm. 2012;69:865-70. [12] Enayatallah SA, et al. A study of hepatoprotective activity of Ocimum sanctum (Krishna tulas) extracts in chemically induced liver damage in albino mice. J Ecophysiol Occup Health. 2004;4:89-96. [13] Karamala SK, et al. Hematobiochemical changes of lead poisoning and amelioration with Ocimum sanctum in Wistar albino rats. Vet World. 2011;4:260-3. [14] Sharma MK, et al. Ocimum sanctum aqueous leaf extract provides protection against mercury induced toxicity in Swiss albino mice. Indian J Exp Biol. 2002;40:1079-82. [15] Samson J, et al. Oxidative stress in brain and antioxidant activity of Ocimum sanctum in noise exposure. Neurotoxicology. 2007;28:679-85. [16] Archana R, Namasivayam A. A comparative study of different crude extracts of Ocimum sanctum on noise stress. Phytother Res. 2002;16:579-80. [17] Sembulingam K, et al. Effect of Ocimum sanctum Linn. on changes in leucocytes of albino rats induced by acute noise stress. Indian J Physiol Pharmacol. 1999;43:137-40. [18] Can A, et al. The mouse forced swim test. J Vis Exp. 2012 Jan 29;(59):e3638. [19] Sembulingam K, et al. Effect of Ocimum sanctum Linn. on the changes in central cholinergic system induced by acute noise stress. J Ethnopharmacol. 2005 Jan 15;96(3):477-82. [20] Sembulingam K, et al. Effect of Ocimum sanctum Linn. on noise induced changes in plasma corticosterone level. Indian J Physiol Pharmacol. 1997 Oct;41(4):429-30. [21] Archana R, Namasivayam A. Effect of Ocimum sanctum on noise induced changes in neutrophil functions. J Ethnopharmacol. 2000 Nov;73(1-2):81-5. [22] Kothari A, Sharma S. Evaluation of anti-inflammatory effect of fresh tulsi leaves (Ocimum sanctum) against different mediators of inflammation in albino rats. Int J Pharm Sci Rev Res. 2012;14:119-23. [23] Sampath S, et al. Holy basil (Ocimum sanctum Linn.) leaf extract enhances specific cognitive parameters in healthy adult volunteers: a placebo controlled study. Indian J Physiol Pharmacol. 2015 Jan-Mar;59(1):69-77. [24] Giridharan VV, et al. Ocimum sanctum Linn. leaf extracts inhibit acetylcholinesterase and improve cognition in rats with experimentally induced dementia. J Med Food. 2011;14:912-9. [25] Joshi H, Parle M. Cholinergic basis of memory improving effect of Ocimum tenuiflorum Linn. Indian J Pharm Sci. 2006;68:364-5. [26] Ahmad MZ, et al. Anti-diabetic activity of Ocimum sanctum L. roots and isolation of new phytoconstituents using two-dimensional nuclear magnetic resonance spectroscopy. J Pharmacogn Phytother. 2012;4:75-85. [27] Devra DK, et al. Effect of tulsi (Ocimum sanctum Linn.) on clinical and biochemical parameters of metabolic syndrome. J Nat Remedies. 2012;12:63-7. [28] Suanarunsawat T, et al. Lipid-lowering and antioxidative activities of aqueous extracts of Ocimum sanctum L. leaves in rats fed with a high-cholesterol diet. Oxid Med Cell Longev. 2011;2011:962025. [29] Singh S, et al. Effect of Ocimum sanctum fixed oil on blood pressure, blood clotting time and pentobarbitone-induced sleeping time. J Ethnopharmacol. 2001 Dec;78(2-3):139-43. [30] Chatterjee M, et al. Evaluation of ethanol leaf extract of Ocimum sanctum in experimental models of anxiety and depression. Pharm Biol. 2011;49:477-83. [31] Tabassum I, et al. Effects of Ocimum sanctum and Camellia sinensis on stress-induced anxiety and depression in male albino Rattus norvegicus. Indian J Pharmacol. 2010;42:283-8. [32] Bhattacharyya D, et al. Controlled programmed trial of Ocimum sanctum leaf on generalized anxiety disorders. Nepal Med Coll J. 2008;10:176-9. [33] Moinuddin G, et al. Comparative pharmacological evaluation of Ocimum sanctum and imipramine for antidepressant activity. Lat Am J Pharm. 2011;30:435-9. [34] Saxena RC, et al. Efficacy of an extract of Ocimum tenuiflorum (OciBest) in the management of general stress: A double-blind, placebo-controlled study. Evid Based Complement Alternat Med. 2012;2012:894509. [35] Cohen MM. Tulsi – Ocimum sanctum: a herb for all reasons. J Ayurveda Integr Med. 2014 Oct-Dec;5(4):251-9. [36] Olsson EM, et al. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract SHR-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. 2009 Feb;75(2):105-12. [37] Lekomtseva Y, et al. Rhodiola rosea in subjects with prolonged or chronic fatigue symptoms: results of an open-label clinical trial. Complement Med Res. 2017;24(1):46-52. [38] Spasov AA, et al. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. 2000 Apr;7(2):85-9. [39] Shevtsov VA, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine. 2003 Mar;10(2-3):95-105. [40] Lishmanov I, et al. The anti-arrhythmic effect of Rhodiola rosea and its possible mechanism. Biull Eksp Biol Med. 1993 Aug;116(8):175-6. [41] Maslova LV, et al. The cardioprotective and antiadrenergic activity of an extract of Rhodiola rosea in stress. Eksp Lkin Farmakol. 1994 Nov;57(6):61-3. [42] Noreen EE, et al. The effects of an acute dose of Rhodiola rosea on endurance exercise performance. J Strength Cond Res. 2013 Mar;27(3):839-47. [43] Edwards D, et al. Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms – results of an open-label study. Phytother Res. 2012 Aug;26(8):1220-5. [44] Kasper S, Dienel A. Multicenter, open-label, exploratory clinical trial with Rhodiola rosea extract in patients suffering from burnout symptoms. Neuropsychiatr Dis Treat. 2017;13:889-98. [45] van Diermen D, et al. Monoamine oxidase inhibition by Rhodiola rosea L. roots. J Ethnopharmacol. 2009 Mar 18;122(2):397-401. [46] Chan SW, et al. Panax ginseng, Rhodiola rosea and Schisandra chinensis. Int J Food Sci Nutr. 2012 Mar;63 Suppl 1:75-81. [47] Qureshi NA, Al-Bedah AM. Mood disorders and complementary and alternative medicine: a literature review. Neuropsychiatr Dis Treat. 2013;9:639-58. [48] Darbinyan V, et al. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nord J Psychiatry. 2007;61(5):343-8. [49] Krasik ED, et al. Therapy of asthenic conditions: clinical perspectives of application of Rhodiola rosea extract (golden root). Proceedings Modern Problems in Psychopharmacology, Kemerovo. 1970 May:298-300. [50] Brichenko, et al. The use of herbal adaptogens with tricyclic antidepressants in patients with psychodenic depression. Modern Problems of Pharmacology and Search for New Medicines. 1986;2:58-60. [51] Maniscalco I, et al. [The interaction of Rhodiola rosea and antidepressants. A case report]. Neuropsychiatr. 2015;29(1):36-8.
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Dr. Erica Zelfand
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